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- Title
Pumping up the Fight against Multiple Sclerosis: The Effects of High-Intensity Resistance Training on Functional Capacity, Muscle Mass, and Axonal Damage.
- Authors
Maroto-Izquierdo, Sergio; Mulero, Patricia; Menéndez, Héctor; Pinto-Fraga, José; Lista, Simone; Santos-Lozano, Alejandro; Téllez, Nieves
- Abstract
Background: Resistance training (RT) has been recognized as a beneficial non-pharmacological intervention for multiple sclerosis (MS) patients, but its impact on neurodegeneration is not fully understood. This study aimed to investigate the effects of high-intensity RT on muscle mass, strength, functional capacity, and axonal damage in MS patients. Methods: Eleven relapsing–remitting MS patients volunteered in this within-subject counterbalanced intervention study. Serum neurofilament light-chain (NfL) concentration, vastus lateralis thickness (VL), timed up-and-go test (TUG), sit-to-stand test (60STS), and maximal voluntary isometric contraction (MVIC) were measured before and after intervention. Participants performed 18 sessions of high-intensity RT (70–80% 1-RM) over 6 weeks. Results: Significant (p < 0.05) differences were observed post-intervention for VL (ES = 2.15), TUG (ES = 1.98), 60STS (ES = 1.70), MVIC (ES = 1.78), and NfL (ES = 1.43). Although moderate correlations between changes in VL (R = 0.434), TUG (R = −0.536), and MVIC (R = 0.477) and changes in NfL were observed, only the correlation between VL and MVIC changes was significant (R = 0.684, p = 0.029). Conclusions: A 6-week RT program significantly increased muscle mass, functional capacity, and neuromuscular function while also decreasing serum NfL in MS patients. These results suggest the effectiveness of RT as a non-pharmacological approach to mitigate neurodegeneration while improving functional capacity in MS patients.
- Subjects
MULTIPLE sclerosis prevention; EXERCISE physiology; MULTIPLE sclerosis; SKELETAL muscle; DATA analysis; HIGH-intensity interval training; CLINICAL trials; QUESTIONNAIRES; FUNCTIONAL status; DESCRIPTIVE statistics; RESISTANCE training; MUSCLE strength; NERVE tissue proteins; CONTROL groups; PRE-tests &; post-tests; LONGITUDINAL method; CYTOPLASM; STATISTICS; ANALYSIS of variance; QUADRICEPS muscle; BODY movement; COMPARATIVE studies; DATA analysis software; MUSCLE contraction; DISEASE complications
- Publication
Healthcare (2227-9032), 2024, Vol 12, Issue 8, p837
- ISSN
2227-9032
- Publication type
Article
- DOI
10.3390/healthcare12080837