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- Title
Front Cover: One‐Step Nickel‐Catalyzed Synthesis of Alpha‐Arylidene and Gamma Hydroxy‐Substituted N‐Methyl‐2‐Pyrrolidones (Asian J. Org. Chem. 6/2024).
- Authors
Sirvin Rajan, Robin Prakash; Mok, Jungwi; Lee, Junseong; Lee, Sunwoo
- Abstract
The Asian Journal of Organic Chemistry features an article by Sunwoo Lee and co-workers that presents a new synthetic methodology. The method efficiently combines N-methyl-2-pyrrolidone (NMP) with various aryl aldehydes to produce compounds with an arylidene group at the alpha position and an alcohol group at the gamma position. The synthesis uses Ni(glyme)Cl2 as a catalyst and tert-butyl hydroperoxide as an oxidant, resulting in high yields. This innovative approach demonstrates versatility and efficiency in organic synthesis.
- Subjects
OXIDIZING agents; MOIETIES (Chemistry); ALDEHYDES
- Publication
Asian Journal of Organic Chemistry, 2024, Vol 13, Issue 6, p1
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202480601