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- Title
Subcentimeter Corticotroph Adenoma: an Evaluation of Diagnostic Elements.
- Authors
Yin Ye Lai; Thambiah, Subashini C.; Mokhtar, Normaizuwana; Samsudin, Intan Nureslyna
- Abstract
Cushing's disease (CD) is an uncommon yet serious disorder, linked to increased morbidity and mortality. Diagnosis of these patients are complex, and emphasis should be placed on early detection for better management of these patients. The objective of this case report is to evaluate the diagnostic elements in the identification of a subcentimeter adrenocorticotrophic hormone (ACTH)-dependent pituitary adenoma. We report a case of a 26-year-old man who presented with extensive superficial fungal infection of the skin, unintentional weight gain, hypertension, dyslipidaemia as well as cushingoid appearance suspicious of hypercortisolism. Raised midnight plasma cortisol and 24-hour urinary cortisol levels warranted further investigation. Overnight and 48-hour low-dose dexamethasone suppression test (LDDST) were non-suppressed. Subsequent bilateral inferior petrosal sinus sampling (BIPSS) was not only efficient in differentiating pituitary from ectopic Cushing's syndrome (CS) but was shown to be superior to magnetic resonance imaging (MRI) in lateralisation of the pituitary adenoma.
- Subjects
CUSHING'S syndrome; PITUITARY tumors; ADENOMA; MAGNETIC resonance imaging; MYCOSES; PITUITARY cancer
- Publication
Malaysian Journal of Medicine & Health Sciences, 2023, Vol 19, p58
- ISSN
1675-8544
- Publication type
Case Study
- DOI
10.47836/mjmhs.19.s16.10