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- Title
Evaluating Antibacterial Properties of TAT-Peptide Conjugated Copper Oxide Nanoparticles Biosynthesised from Aspergillus Species.
- Authors
Muthukumarasamy, Ravindran; Nizar, Ku Allyssa Nadhira Binti Ku Aizul; Majeed, Shahnaz; Danish, Mohammad; Ibrahim, M. N. Mohamad
- Abstract
Introduction: The increasing prevalence of antibiotic resistant bacteria and their detrimental effects have further highlighted the need to develop novel antibacterial agents. This study explored the antibacterial properties of TAT-peptide-conjugated copper oxide nanoparticles (cCuONPs) biosynthesised from Aspergillus species. Methods: The biosynthesis of copper oxide nanoparticles was achieved through an eco-friendly and cost-effective approach using Aspergillus species as a bio-reducing agent, followed by capping with TAT-peptide. The synthesised nanoparticles were characterised using various analytical techniques, including UV-visible spectroscopy, FTIR, TEM, SEM, TGA, and DSC. The findings reported the successful formation of cCuONPs. Results: The UV-Vis spectroscopy showed the characteristic absorption peak of cCuONPs at 237 nm. The FTIR results confirm the associated functional groups of cCuO NPs. TEM results revealed the particle size of cCuO NPs at a range of 5 to 10 nm; SEM results revealed cCuO NPs are of spherical nanostructures and EDX analysis confirmed the presence of elements such as Cu and O in the sample. The DSC analysis identified two peaks expressing endothermic reactions. Furthermore, the antibacterial activity of the cCuO NPs was evaluated against selected gram-positive and negative strains. Conclusion: The results showed a significant enhancement in antibacterial efficacy and positive synergistic activity on tested bacteria, indicating the potential of cCuONPs for targeted bacterial inhibition. Biosynthesised nanoparticles have shown promising properties and could become potential therapeutic agents for combating antibiotic resistant bacteria. Further investigations are recommended to explore their mechanism of action, toxicity profiles, for their potential applications in the biomedical and pharmaceutical fields.
- Subjects
COPPER oxide; DRUG resistance in bacteria; ASPERGILLUS; ENDOTHERMIC reactions; NANOPARTICLES; PEPTIDE antibiotics
- Publication
Malaysian Journal of Medicine & Health Sciences, 2023, Vol 19, p30
- ISSN
1675-8544
- Publication type
Article