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- Title
Navigating an unexpected diagnosis - experience of a tertiary referral centre with two cases of intraplacental choriocarcinoma.
- Authors
Chun Wei, Caleb LIM; PUNJABI, Lavisha S.; BHATIA, Anju; Qiu Ju NG; JEVON, Gareth Peter; AGGARWAL, Ieera Madan
- Abstract
Intraplacental choriocarcinoma is a rare tumour, with approximately 62 reported cases. It may manifest as a spectrum of disease ranging from an incidental lesion diagnosed on routine placental examination to disseminated maternal and/or neonatal disease. In this case series, we presented two rare cases of intraplacental choriocarcinoma with extremely varied clinical presentations. The extremely varied clinical presentations of both patients described in the case series complicated the process of arriving at the diagnosis. In both cases, subsequent investigations showed no maternal or neonatal metastasis, and maternal serum beta-hCG levels downtrended with conservative management. We aim to highlight the importance of performing a detailed physical examination and evaluation of the patient and multidisciplinary management with oncology opinion. A detailed examination of the placenta should also be considered when faced with obstetric complications so that early diagnosis and the required management can be executed in a prompt fashion.
- Subjects
CHORIOCARCINOMA; SYMPTOMS; DIAGNOSIS; GESTATIONAL trophoblastic disease; NEONATAL diseases
- Publication
Malaysian Journal of Pathology, 2024, Vol 46, Issue 1, p91
- ISSN
0126-8635
- Publication type
Case Study