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- Title
Suppression of UV-induced damage by a liposomal sunscreen: a prospective, open-label study in patients with cutaneous lupus erythematosus and healthy controls.
- Authors
Patsinakidis, Nikolaos; Wenzel, Joerg; Landmann, Aysche; Koch, Raphael; Gerß, Joachim; Luger, Thomas A.; Metze, Dieter; Surber, Christian; Kuhn, Annegret
- Abstract
This study aimed to determine whether a broad-spectrum liposomal sunscreen with a very high sun protection factor ( Daylong actinica) can prevent damage induced by ultraviolet ( UV) irradiation in patients with cutaneous lupus erythematosus ( CLE) and healthy controls ( HCs) under standardised conditions. In 20 patients with CLE and 10 HCs, defined areas of sunscreen-untreated and sunscreen-treated skin on the upper back were irradiated with combined UVA/ UVB light. Disease-specific skin lesions were induced by UVA/ UVB light in the untreated areas of nine patients with CLE; no specific eruptions or any sun damage was observed in the sunscreen-treated areas in any of the CLE patients, nor in the HCs. Histological analysis of skin biopsy specimens confirmed the clinical results. In conclusion, the use of a high-protection, broad-spectrum sunscreen can prevent UV-induced damage in patients with CLE and HCs.
- Subjects
PHYSIOLOGICAL effects of ultraviolet radiation; SUNSCREENS (Cosmetics); LUPUS erythematosus; SKIN diseases; SKIN care
- Publication
Experimental Dermatology, 2012, Vol 21, Issue 12, p958
- ISSN
0906-6705
- Publication type
Article
- DOI
10.1111/exd.12035