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- Title
Diuretic Activity of Gokshuradi Guggulu (A Multi-Herbal Formulation) In Rats.
- Authors
Fernando, W. M. A. L.; Weerasekera, K. R.; Jayakody, J. R. A. C.; Ratnasooriya, W. D.
- Abstract
Gokshuradi guggulu (Gg) is multi-herbal formulation consisting of nine ingredients which is used in Ayurvedic, traditional and folkloric medicine to promote urinary out flow. However, the diuretic potential of Gg has not been validated or refuted. The aim of this study was to investigate the diuretic potential of Gg purchased from Sri Lankan open market using rat hydrated assay. Different doses of Gg (4000, 2000 and 1000 mg /kg) or distilled water (vehicle) or 13 mg/kg of furosemide, the reference drug, was orally administered to 18 h fasted (deprived of water but not food) rats and their cumulative urine output was determined at hourly intervals for 6h. The results raveled that Gg does not possess significant (P> 0.05) diuretic activity (both in term of hourly and cumulative urine output), at the doses tested. It is concluded that Gg purchased from Sri Lankan open market is devoid of any diuretic activity. This is a noval finding with therapeutic implications.
- Subjects
RATS; DIURETICS; HERBAL medicine; DISTILLED water; FUROSEMIDE
- Publication
International Journal of Pharmaceutical Research & Allied Sciences, 2015, Vol 4, Issue 1, p8
- ISSN
2277-3657
- Publication type
Article