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- Title
Determinants of Circulating Adiponectin in Women with Polycystic Ovary Syndrome.
- Authors
Vrbíková, Jana; Dvořáková, Kateřina; Hill, Martin; Včelák, Josef; Stanická, Soňa; Vaňková, Markéta; Šrámková, Daniela; Vondra, Karel; Bendlová, Běla; Stárka, Luboslav
- Abstract
Background and Aim: Adiponectin is regarded as a possible link between adiposity and insulin resistance. Ghrelin and leptin are considered as signals of energy status. We evaluated the relationships between these peptides, androgens and insulin sensitivity in women affected by polycystic ovary syndrome. Methods: Thirty-six women with PCOS were examined with euglycemic hyperinsulinemic clamp (to determine M/I, index of insulin sensitivity). Leptin, ghrelin, adiponectin, androgens, and SHBG were determined. Statistics was done using correlation analysis and backward stepwise multiple regression. Results: The positive correlation of adiponectin with testosterone remains significant even after adjustment for BMI (p = 0.01), M/I (p = 0.009) and for both M/I and BMI (p = 0.02). In multiple regression with testosterone, M/I, leptin and ghrelin as independent variables, the model including testosterone (p = 0.03) and ghrelin (p = 0.002) explained 49% of the variability (p < 0.0012) of adiponectin. Conclusions: Both adiponectin and ghrelin can be involved in the pathophysiology of PCOS but their relation must be delineated further. Copyright © 2005 S. Karger AG, Basel
- Subjects
POLYCYSTIC ovary syndrome; GHRELIN; ANDROGENS; INSULIN resistance; OBESITY
- Publication
Gynecologic & Obstetric Investigation, 2005, Vol 60, Issue 3, p155
- ISSN
0378-7346
- Publication type
Article
- DOI
10.1159/000086273