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- Title
Tenascin is overexpressed in vitiligo lesional skin and inhibits melanocyte adhesion.
- Authors
le Poole, I. C.; van den Wijngaard, R. M. J. G.; Westerhof, W.; Das, P. K.
- Abstract
The aetiology of vitiligo remains obscure. In this study the role of integrins in the observed inability of melanocytes to repopulate lesional skin was investigated. Antibodies directed to α2α3α5α3α6, and β1 and β3 integrin subunits were used. Immunohistology revealed no marked differences iii the overall levels of expression of integrins between control. non-lesional, perilesional or lesional skin. Moreover, no differences were noted in the level of expression of integrins or the adhesive capacity between cultured control cells derived from three separate donors and vitiligo-derived melanocytes from two donors. Rather, it was clearly observed that towards the lesion. vitiligo skin contains increasing amounts of tenascin in the basal membrane and papillary dermis in five patients employing T2H5 antihuman tenascin antibody. The anti-adhesive effect observed in vitro for this extracellular matrix molecule using normal melanocytes may contribute to loss of pigment cells in vitiligo or to ineffective repopulation of the lesions.
- Subjects
EXTRACELLULAR matrix proteins; GLYCOPROTEINS; CELL adhesion molecules; MELANOCYTES; IMMUNOHISTOCHEMISTRY; ETIOLOGY of diseases
- Publication
British Journal of Dermatology, 1997, Vol 137, Issue 2, p171
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1046/j.1365-2133.1997.18011894.x