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- Title
Highly purified omega -- 3 -- polyunsaturated fatty acids for topical treatment of psoriasis. Results of a double-blind, placebo -- controlled multicentre study.
- Authors
Henneicke-Von Zepelin, H.-H.; Mrowietz, U.; Färber, L.; Bruck-Borchers, K.; Schober, C.; Huber, J.; Lutz, G.; Kohnen, R.; Christophers, E.; Welzel, D.
- Abstract
We report the results of a multicentre. double-blind, placebo-controlled study of topical therapy with omega-3-polyunsaturated fatty acids (omega- 3-PUFA) in 52 patients suffering from moderate plaque-type psoriasis. In each patient, two similar stable psoriatic plaques served as indicator lesions for the study. One indicator lesion was randomly assigned to treatment with topical preparations of highly purified omega-3-PUFA in one of two concentrations (1 or 10%). and the other was treated with placebo. Efficacy assessment was based on changes in local psoriasis severity index, area involved, erythema, desquamation. induration and pruritus. After 8 weeks of treatment, all indicator lesions had improved significantly, compared with baseline. However, no statistically or clinically relevant differences between the omega-3-PUFA-treated and the placebo-treated lesions were found. Therapy was well tolerated and. apart from one patient who developed perilesional eczema, no clinically relevant adverse events occurred. In conclusion, topical omega-3-PUFA were not effective in a randomized, placebo-controlled, double-blind setting. Results of non-blind trials should be (re-)considered with caution.
- Subjects
THERAPEUTICS; ECZEMA; PSORIASIS; SKIN diseases; DERMATOLOGIC agents; UNSATURATED fatty acids; PSORIASIS treatment products
- Publication
British Journal of Dermatology, 1993, Vol 129, Issue 6, p713
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1993.tb03338.x