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- Title
Synthetic biology of fungal natural products.
- Authors
Mattern, Derek J.; Valiante, Vito; Unkles, Shiela E.; Brakhage, Axel A.; Schmoll, Monika; Junbiao Dai; Xiaoqiang Jia
- Abstract
Synthetic biology is an ever-expanding field in science, also encompassing the research area of fungal natural product (NP) discovery and production. Until now, different aspects of synthetic biology have been covered in fungal NP studies from the manipulation of different regulatory elements and heterologous expression of biosynthetic pathways to the engineering of different multidomain biosynthetic enzymes such as polyketide synthases or non-ribosomal peptide synthetases. The following review will cover some of the exemplary studies of synthetic biology in filamentous fungi showing the capacity of these eukaryotes to be used as model organisms in the field. From the vast array of different NPs produced to the ease for genetic manipulation, filamentous fungi have proven to be an invaluable source for the further development of synthetic biology tools.
- Subjects
SYNTHETIC biology; NATURAL products; FILAMENTOUS fungi
- Publication
Frontiers in Microbiology, 2015, p1
- ISSN
1664-302X
- Publication type
Article
- DOI
10.3389/fmicb.2015.00775