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- Title
Surface modification by deposition of IPA plasma and gellan gum/chitosan hybrid hydrogel onto thermoplastic polyurethane for controlled release of N‐acetylcysteine.
- Authors
Pan, Jiunn‐An; Liu, Hsuan‐Liang; Ting, Wei‐Ting; Hsu, Hong‐Kai; Chen, Ko‐Shao
- Abstract
A thin film system composed of gellan gum and chitosan was fabricated through a combination of polyelectrolyte blend and hybrid hydrogel gelation for controlled release of drug. In this study, precursor isopropyl alcohol (IPA) was used to plasma deposit on the surface of thermoplastic polyurethane (TPU) to form a hydrophilic film. The features of the thin film were evaluated using water contact angle (WCA) measurement, scanning electron microscopy (SEM), Fourier transform infra‐red (FTIR), UV/Vis spectroscopy, and studies of controlled release of drugs. The hybrid hydrogel, pH‐sensitive, was tested at pH values of 1.2 and 7.4 of buffer solution and at a temperature of 37°C to observe its swelling ratio and drug delivery properties with N‐acetylcysteine as a drug material for controlled release. Furthermore, at pH 7.4, the hybrid hydrogel has an outstanding release ratio of up to about 90% absorption amounts of N‐acetylcysteine after 8 hr. The mechanism of drug release from thin film devices (n = 0.684) is anomalous (non‐Fickian) transport, the value of n lies between 0.43 and 0.85.
- Subjects
GELLAN gum; CHITOSAN; PLASMA deposition; CONTROLLED release drugs; POLYURETHANES; THIN film devices
- Publication
Journal of the Chinese Chemical Society, 2019, Vol 66, Issue 7, p691
- ISSN
0009-4536
- Publication type
Article
- DOI
10.1002/jccs.201800297