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- Title
Surface ultrastructure of SARS coronavirus revealed by atomic force microscopy.
- Authors
Shiming Lin; Chih-Kung Lee; Shih-Yuan Lee; Chuan-Liang Kao; Chii-Wann Lin; An-Bang Wang; Su-Ming Hsu; Long-Sun Huang
- Abstract
Atomic force microscopy has been used to probe the surface nanostructures of severe acute respiratory syndrome coronavirus (SARS-CoV). Single crown-like virion was directly visualized and quantitative measurements of the dimensions for the structural proteins were provided. A corona of large, distinctive spikes in the envelope was measured after treatment with hydroxyoctanoic acid. High-resolution images revealed that the surface of each single SARS-CoV was surrounded with at least 15 spherical spikes having a diameter of 7.29 ± 0.73 nm, which is in close agreement with that of S glycoproteins earlier predicted through the genomes of SARS-CoV. This study represents the first direct characterization of the surface ultrastructures of SARS-CoV particles at the nanometre scale and offers new prospects for mapping viral surface properties.
- Subjects
CORONAVIRUSES; RNA viruses; SARS disease; CORONAVIRUS diseases; RESPIRATORY diseases; ATOMIC force microscopy; VIRUSES
- Publication
Cellular Microbiology, 2005, Vol 7, Issue 12, p1763
- ISSN
1462-5814
- Publication type
Article
- DOI
10.1111/j.1462-5822.2005.00593.x