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- Title
The role of thyroid autoantibodies in the development of thyroid dysfunction in Taiwanese chronic hepatitis C patients with interferon-alpha and ribavirin combination therapy.
- Authors
Huang, J-F.; Chuang, W-L.; Dai, C-Y.; Chen, S-C.; Lin, Z-Y.; Lee, L-P.; Lee, P-L.; Wang, L-Y.; Hsieh, M-Y.; Chang, W-Y.; Yu, M-L.
- Abstract
To investigate the role of thyroid autoantibodies in the development of thyroid dysfunction among chronic hepatitis C (CHC) patients receiving interferon-alpha (IFN-α) plus ribavirin (RBV) combination therapy, 95 Taiwanese naïve patients with baseline euthyroidism were enrolled. They were treated with IFN-α2b, 6 million units thrice weekly, plus RBV 1000–1200 mg daily for 24 weeks. Thyroid function, anti-thyroglobulin and antiperoxidase autoantibodies were tested at enrolment (M0), at the end-of-treatment (M6) and 6 months after end-of-treatment (M12). The percentages of thyroid autoantibodies were 8.4%, 11.6% and 9.5%, at M0, M6 and M12 respectively. Fourteen (14.7%) patients developed thyroid dysfunction at M6 or M12. Thyroid dysfunction occurred during treatment in five (62.5%) of the eight patients with baseline thyroid autoantibodies, which was significantly higher than nine (10.3%) of 87 patients without baseline thyroid autoantibodies ( P = 0.0001). Among 14 patients who developed thyroid dysfunction, four (80.0%) of five patients with baseline thyroid autoantibodies recovered at M12, in contrast to two (25%) of eight without baseline thyroid autoantibodies recovered at M12 ( P < 0.05). In conclusion, thyroid autoantibodies, either occurred before or during IFN- α plus RBV combination therapy, carry a high prediction of subsequent thyroid dysfunction. There also exists difference in the clinical manifestations of thyroid dysfunction in CHC patients treated with combination therapy.
- Subjects
AUTOANTIBODIES; RIBAVIRIN; THYROID gland; HEPATITIS C; INTERFERONS; LIVER diseases
- Publication
Journal of Viral Hepatitis, 2006, Vol 13, Issue 6, p396
- ISSN
1352-0504
- Publication type
Article
- DOI
10.1111/j.1365-2893.2005.00705.x