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- Title
Parental age and the origin of extra chromosome 21 in Down syndrome.
- Authors
Jyothy, A.; Kumar, K. S. D.; Rao, G.N. Mallikarjuna; Rao, V. Babu; Devi, B. Uma; Sujatha, M.; Reddy, P. P.
- Abstract
Abstract We present a report of the parental ages (n = 865) and parental origin of meiotic nondisjunction (n = 236) that are likely to show a predisposition in the etiology of Down syndrome (DS). Chromosomal analysis, performed over a 20-year period, on 1001 Down syndrome subjects, revealed pure trisomy 21 karyotype in 880 subjects (87.92%), mosaic trisomy karyotype in 77 (7.69%), and translocation karyotype in 44 (4.39%). The mean maternal age was found to be 30.34 years, and mean paternal age was 31.04 years. Nondisjunctional error was 79.24% maternal and 20.76% paternal. The findings of the study revealed the significant contribution of advanced parental age and increased maternal meiotic nondisjunctional error to the origin of trisomy 21 Down syndrome.
- Subjects
DOWN syndrome; CHROMOSOME analysis; MEIOSIS; ETIOLOGY of diseases
- Publication
Journal of Human Genetics, 2001, Vol 46, Issue 6, p347
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1007/s100380170071