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- Title
Isolation and radiation hybrid mapping of dinucleotide repeat polymorphism at the human matrix Gla protein (MGP) locus.
- Authors
Watanabe, Ikuyo; Tsukamoto, Kazuhiro; Shiba, Tadayoshi; Emi, M.
- Abstract
Abstract Matrix Gla protein (MGP) is an 84-residue, vitamin K-dependent protein expressed by chondrocytes and vascular smooth muscle cells, and is a potent regulator of calcium deposition in cartilage and arterial wall. We isolated a polymorphic dinucleotide CA repeat marker from a genomic clone containing the human MGP gene. This polymorphism will be useful in genetic studies of arteriosclerosis and osteoporosis.
- Subjects
GENETIC polymorphisms; CALCIUM in the body; HUMAN genetics
- Publication
Journal of Human Genetics, 1998, Vol 43, Issue 1, p75
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1007/s100380050044