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- Title
Fatal Case of Chronic Jamestown Canyon Virus Encephalitis Diagnosed by Metagenomic Sequencing in Patient Receiving Rituximab.
- Authors
Solomon, Isaac H.; Ganesh, Vijay S.; Guixia Yu; Xian Ding Deng; Wilson, Michael R.; Miller, Steve; Milligan, Tracey A.; Mukerji, Shibani S.; Mathewson, Abigail; Linxweiler, Justin; Morse, Darlene; Ritter, Jana M.; Staples, J. Erin; Hughes, Holly; Gould, Carolyn V.; Sabeti, Pardis C.; Chiu, Charles Y.; Piantadosi, Anne; Yu, Guixia; Deng, Xian Ding
- Abstract
A 56-year-old man receiving rituximab who had months of neurologic symptoms was found to have Jamestown Canyon virus in cerebrospinal fluid by clinical metagenomic sequencing. The patient died, and postmortem examination revealed extensive neuropathologic abnormalities. Deep sequencing enabled detailed characterization of viral genomes from the cerebrospinal fluid, cerebellum, and cerebral cortex.
- Subjects
RESEARCH; RESEARCH methodology; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; GENOMES; RESEARCH funding; RNA viruses; VIRAL antibodies
- Publication
Emerging Infectious Diseases, 2021, Vol 27, Issue 1, p238
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2701.203448