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- Title
Utility of Whole-Genome Sequencing to Ascertain Locally Acquired Cases of Coccidioidomycosis, Washington, USA.
- Authors
Oltean, Hanna N.; Etienne, Kizee A.; Roe, Chandler C.; Gade, Lalitha; McCotter, Orion Z.; Engelthaler, David M.; Litvintseva, Anastasia P.
- Abstract
Coccidioidomycosis is an emerging fungal infection in Washington, USA, and the epidemiology of the disease in this state is poorly understood. We used whole-genome sequencing to differentiate locally acquired cases in Washington on the basis of the previously identified phylogeographic population structure of Coccidioides spp. Clinical isolates from coccidioidomycosis cases involving possible Washington soil exposure were included. Of 17 human infections with epidemiologic evidence of possible local acquisition, 4 were likely locally acquired infections and 13 were likely acquired outside Washington. Isolates from locally acquired cases clustered within the previously established Washington clade of C. immitis. Genetic differences among these strains suggest multiple environmental reservoirs of C. immitis in the state.
- Subjects
UNITED States; COCCIDIOIDOMYCOSIS; EMERGING infectious diseases; MYCOSES; DISEASE progression; EPIDEMIOLOGY
- Publication
Emerging Infectious Diseases, 2019, Vol 25, Issue 3, p501
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2503.181155