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- Title
Substance Use and Adherence to HIV Preexposure Prophylaxis for Men Who Have Sex with Men<sup>1</sup>.
- Authors
Hoenigl, Martin; Jain, Sonia; Moore, David; Collins, Deborah; Xiaoying Sun; Anderson, Peter L.; Corado, Katya; Blumenthal, Jill S.; Daar, Eric S.; Milam, Joel; Dubé, Michael P.; Morris, Sheldon; Sun, Xiaoying; California Collaborative Treatment Group 595 Team
- Abstract
The effectiveness of oral HIV preexposure prophylaxis (PrEP) strongly depends on maintaining adherence. We investigated the association between substance use and PrEP adherence, as well as incident sexually transmitted infections (STIs) in a high-risk cohort of 394 participants (391 men who have sex with men and 3 transgender women) who were enrolled in a PrEP demonstration project. We assessed baseline and ongoing substance use over a 48-week period for stimulants and nonstimulant substances and for each substance separately. We measured PrEP adherence by using dried blood spots to obtain levels of tenofovir diphosphate. No differences in these levels were found between substance users and nonsubstance users. Baseline stimulant use was strongly associated (odds ratio 3.4; p<0.001) with incident STIs during the study. Thus, PrEP adherence was not decreased by substance use. Because substance users had increased rates of STIs, indicating higher-risk behavior, they might be excellent candidates for PrEP.
- Subjects
SUBSTANCE abuse; MEN who have sex with men; HIV-positive persons; SEXUALLY transmitted diseases; TENOFOVIR
- Publication
Emerging Infectious Diseases, 2018, Vol 24, Issue 12, p2292
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2412.180400