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- Title
HIV-associated multiple intracranial aneurysms and stroke in an adult patient: successful treatment with a combination of glucocorticoid and antiviral agents.
- Authors
Sabi, Mohsen Soltani; Mousavian, Pourandokht; Sasannejad, Payam; Hezarkhani, Leila Afshar; Salimnia, Nasrin; Oryani, Mahsa Akbari; Malekzadeh, Mohammadreza; Moosavian, Hamidreza
- Abstract
A 35-year-old Iranian man with an 18-year history of human immunodeficiency virus (HIV) infection developed sudden left-sided hemiparesis and mild dysarthria. Based on laboratory results, brain and neck computerized tomography angiography (CTA), echocardiography, hypercoagulability tests, and vasculitis tests, the patient was diagnosed with a stroke with multiple intracranial aneurysms secondary to HIV. Cerebral aneurysms and stroke are uncommon in HIV-infected patients, and the aneurysms' exact cause and risk factors are unknown. There is currently no effective regimen or definitive treatment for HIV-associated vasculitis. In the present study, the patient recovered without any neurological deficits following treatment with oral prednisolone, combined with combination antiretroviral therapy (cART), valacyclovir, and antiplatelet medication. Furthermore, after 2 months of immunosuppressive treatment, all imaging abnormalities improved, and no new events were observed at the 20-month follow-up. To the best of our knowledge, this is the first case in which a patient with HIV-associated vasculopathy and stroke has survived successfully, and all angiographic abnormalities completely eliminated.
- Subjects
INTRACRANIAL aneurysms; HIV; ANTIVIRAL agents; STROKE patients; TREATMENT effectiveness; STROKE; PLATELET aggregation inhibitors
- Publication
Journal of NeuroVirology, 2023, Vol 29, Issue 1, p106
- ISSN
1355-0284
- Publication type
Article
- DOI
10.1007/s13365-022-01106-y