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- Title
Comparison of user-friendliness and treatment cost of Loceryl<sup>®</sup> vs. Ciclopoli<sup>®</sup> - a patient's perspective.
- Authors
Schaller, M.; Braunsdorf, C.; Mailänder‐Sanchez, D.; Jäckel, A.; Müller, J.; Borelli, C.
- Abstract
Topical monotherapy is a valid therapeutic approach in onychomycosis. Due to its lengthy course and its non-reimbursed product status, cost and compliance are important issues and non-pharmacological properties such as over-the-counter price and ease of use should be considered when deciding which product to recommend. We investigated surrogate parameters for patient-friendliness and treatment cost in Germany in a questionnaire-based prospective, comparative, intra-individual, open-label trial of the two common topical antifungal nail lacquers Loceryl® (amorolfine 5%) and Ciclopoli® (ciclopirox 8%) in eight patients with clinically diagnosed onychomycosis. The 2.5 ml bottle of Loceryl® covered a treatment period of 308 days, resulting in treatment costs of €0.10 per day in comparison to the 3.3 ml bottle of Ciclopoli®, covering 127 days at €0.21 per day, given once-daily application for Ciclopoli® and once-weekly application for Loceryl® in accordance with regulatory approval. Six out of eight patients favoured the Loceryl® treatment regimen. Furthermore, four out of eight patients found Loceryl® easier to apply, whereas three preferred Ciclopoli®. In total, seven out of eight stated a clear preference for Loceryl® over Ciclopoli®. Loceryl® therapy is less expensive and less time-consuming. The therapeutic period that can be covered is longer and more patients stated a clear preference for Loceryl® in comparison to Ciclopoli®. The differences are statistically significant, underlining probable clinical relevance.
- Subjects
ONYCHOMYCOSIS; MEDICAL care costs; PATIENT-centered care; CICLOPIROX; LACQUERS; ANTIFUNGAL agents; PATIENT participation; THERAPEUTICS
- Publication
Mycoses, 2015, Vol 58, Issue 10, p632
- ISSN
0933-7407
- Publication type
Article
- DOI
10.1111/myc.12371