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- Title
In vitro effects of lonidamine and 6-aminonicotinamide against Echinococcus granulosus sensu stricto and Echinococcus multilocularis.
- Authors
Qi Xin; Miaomiao Yuan; Huanping Li; Xiaoxia Song; Jun Lu; Tao Jing
- Abstract
Echinococcosis is a zoonotic disease caused by cestode species of the genus Echinococcus, which demonstrates considerable medical and veterinary concerns. The development of novel drugs for echinococcosis treatment is urgently needed. In this study, we demonstrated that lonidamine (LND) and 6-aminonicotinamide (6-AN) exhibited considerable in vitro effects against both larval- and adult-stage of E. granulosus sensu stricto (s. s.) and E. multilocularis. The combination of LND and 6-AN exhibited a significantly higher activity than the single drug treatment. These results highlight the therapeutic potential of LND, 6-AN and the combination of LND and 6-AN for the treatment of echinococcosis.
- Subjects
ECHINOCOCCUS multilocularis; ECHINOCOCCUS granulosus; TAPEWORM infections; ZOONOSES; ECHINOCOCCUS; DRUG development
- Publication
Veterinary Research, 2020, Vol 51, p1
- ISSN
0928-4249
- Publication type
Article
- DOI
10.1186/s13567-020-00744-6