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- Title
Naltrexone ER/Bupropion ER: A Review in Obesity Management.
- Authors
Greig, Sarah; Keating, Gillian
- Abstract
Oral naltrexone extended-release/bupropion extended-release (naltrexone ER/bupropion ER; Contrave, Mysimba™) is available as an adjunct to a reduced-calorie diet and increased physical activity in adults with an initial body mass index (BMI) of ≥30 kg/m (i.e. obese) or a BMI of ≥27 kg/m (i.e. overweight) in the presence of at least one bodyweight-related comorbidity, such as type 2 diabetes mellitus, hypertension or dyslipidaemia. In 56-week phase III trials in these patient populations, oral naltrexone ER/bupropion ER 32/360 mg/day was significantly more effective than placebo with regard to percentage bodyweight reductions from baseline and the proportion of patients who achieved bodyweight reductions of ≥5 and ≥10 %. Significantly greater improvements in several cardiometabolic risk factors were also observed with naltrexone ER/bupropion ER versus placebo, as well as greater improvements in glycated haemoglobin levels in obese or overweight adults with type 2 diabetes. Naltrexone ER/bupropion ER was generally well tolerated in phase III trials, with nausea being the most common adverse event. Thus, naltrexone ER/bupropion ER 32/360 mg/day as an adjunct to a reduced-calorie diet and increased physical activity, is an effective and well tolerated option for chronic bodyweight management in obese adults or overweight adults with at least one bodyweight-related comorbidity.
- Subjects
NALTREXONE; BUPROPION; OBESITY treatment; DISEASE management; BODY mass index; GLYCOSYLATED hemoglobin; DYSLIPIDEMIA; HYPERTENSION
- Publication
Drugs, 2015, Vol 75, Issue 11, p1269
- ISSN
0012-6667
- Publication type
Journal Article
- DOI
10.1007/s40265-015-0427-5