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- Title
Synthesis of New 1,3,4-Thiadiazines Capable of Inhibiting Nonenzymatic Glycosylation of Proteins.
- Authors
Sidorova, L.; Tseitler, T.; Perova, N.; Emel'yanov, V.; Savateeva, E.; Maksimova, N.; Mochul'skaya, N.; Chereshnev, V.; Chupakhin, O.
- Abstract
A series of new 1,3,4-thiadiazines with cycloalkylamino (cyclopropylamino, cyclobutylamino, cyclopentylamino, cyclohexylamino) groups were synthesized via cyclocondensation of α-haloacetophenones with thiosemicarbazides containing 4-cycloalkyl groups. Five of the synthesized compounds showed the capability to inhibit nonenzymatic glycosylation of proteins in vitro in a model system. The obtained test results allowed compounds containing cyclopropylamino residues ( LT-1a and LT-1d) to be recommended for further in vivo testing.
- Subjects
ORGANIC compound derivatives; ORGANIC synthesis; PROTEINS; GLYCOSYLATION; CYCLOALKYL group; IN vitro studies
- Publication
Pharmaceutical Chemistry Journal, 2015, Vol 49, Issue 8, p501
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-015-1314-9