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- Title
Extraction, composition and the antioxidant and anticomplement activities of high molecular weight fractions from the leaves of Symphytum asperum and S. caucasicum.
- Authors
Barbakadze, V.; Mulkidzhanyan, K.; Merlani, M.; Gogilashvili, L.; Amiranashvili, L.; Shaburishvili, E.
- Abstract
High molecular weight fractions (> 1000 kDal) from the leaves of Symphytum asperum and S. caucasicum had anticomplement activity, were able to inhibit luminol- and lucigenin-dependent chemiluminescence (CL and CL respectively) induced by human polymorphonuclear neutrophils (PMN) after stimulation with opsonized zymosan, and could decrease the CL signal induced by superoxide anion formation in a cell-free hypoxanthine/xanthine oxidase system. The anticomplement and antioxidant activities of the high molecular weight fractions (> 1000 kDal) from the leaves of Symphytum asperum and S. caucasicum indicate that they might be used as anti-inflammatory and wound-healing agents.
- Subjects
EXTRACTION (Chemistry); CHEMICAL composition of plants; ANTIOXIDANTS; MOLECULAR weights; COMFREY; LEAVES; CHEMILUMINESCENCE; XANTHINE; WOUND healing; ANTI-inflammatory agents
- Publication
Pharmaceutical Chemistry Journal, 2011, Vol 44, Issue 11, p604
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-011-0527-9