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- Title
Evalution of Analgesic, Antipyretic and Anti-inflammatory Activities of the Leaves Extract of Militaria heterophylla (Lour.) Cogn.
- Authors
Dwivedi, Shivendra Kumar; Jain, Neetesh Kumar
- Abstract
The leaves of Melothria heterophylla (Lour.) was traditional use in Mizoram. The biological evaluation and validation of this leaves extractshowsan anti-inflammatory, analgesic, and antipyretic activities. The alcoholic extract such as methanolic leaves extract of Melothria heterophylla (MMH) was evaluated for its anti-inflammatory, analgesic and antipyretic potential and for acute toxicity in animal models at different doses at a time interval. The leaves of Melothria heterophylla has been found to be safe up to a dose of 3 g/kg when administered orally to the mice. Melothria heterophylla exhibited a significant acute anti-inflammatory effect in the carrageenan-induced rat paw edema test. A significant analgesic effect has been observed in rats when tested by chemical as well as thermal methods using tail flick method, hot plate method and acetic acid-induced writhing test. Melothria heterophylla is also exhibited antipyretic activity in diptheria, tetanus and pertussis (DPT) vaccine - induced pyrexia model and yeast-induced pyrexia model. Pharmacological activities of plant were observed and provide the scientific basis for the folkloric use of the plant in treating inflammation, fever, and pain. The current results proved that the leaves of Melothria heterophylla (Lour.) Cogn traditionally used and having a good potential activity such as anti-inflammatory, analgesic, and antipyretic activities.
- Subjects
MIZORAM (India); ANALGESICS; CHEMICAL testing; EXTRACTS; TETANUS; ANIMAL models in research; FOOT
- Publication
International Journal of Pharmacy & Life Sciences, 2020, Vol 11, Issue 7, p63
- ISSN
0976-7126
- Publication type
Article