We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The composition and roles of gastric stem cells in epithelial homeostasis, regeneration, and tumorigenesis.
- Authors
Liu, Meng; Liu, Qin; Zou, Qiang; Li, Jinyang; Chu, Zhaole; Xiang, Junyu; Chen, Wei-Qing; Miao, Zhi-Feng; Wang, Bin
- Abstract
The epithelial lining of the stomach undergoes rapid turnover to preserve its structural and functional integrity, a process driven by long-lived stem cells residing in the antral and corpus glands. Several subpopulations of gastric stem cells have been identified and their phenotypic and functional diversities linked to spatiotemporal specification of stem cells niches. Here, we review the biological features of gastric stem cells at various locations of the stomach under homeostatic conditions, as demonstrated by reporter mice, lineage tracing, and single cell sequencing. We also review the role of gastric stem cells in epithelial regeneration in response to injury. Moreover, we discuss emerging evidence demonstrating that accumulation of oncogenic drivers or alteration of stemness signaling pathways in gastric stem cells promotes gastric cancer. Given a fundamental role of the microenvironment, this review highlights the role reprogramming of niche components and signaling pathways under pathological conditions in dictating stem cell fate. Several outstanding issues are raised, such as the relevance of stem cell heterogeneity and plasticity, and epigenetic regulatory mechanisms, to Helicobacter pylori infection-initiated metaplasia-carcinogenesis cascades. With the development of spatiotemporal genomics, transcriptomics, and proteomics, as well as multiplexed screening and tracing approaches, we anticipate that more precise definition and characterization of gastric stem cells, and the crosstalk with their niche will be delineated in the near future. Rational exploitation and proper translation of these findings may bring forward novel modalities for epithelial rejuvenation and cancer therapeutics.
- Subjects
STEM cells; STEM cell niches; EPITHELIAL cells; HOMEOSTASIS; CELL differentiation; NEUROPEPTIDE Y
- Publication
Cellular Oncology (2211-3428), 2023, Vol 46, Issue 4, p867
- ISSN
2211-3428
- Publication type
Article
- DOI
10.1007/s13402-023-00802-z