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- Title
High-density lipoprotein cholesterol: How High.
- Authors
Rajagopal, G.; Suresh, V.; Sachan, Alok
- Abstract
The high-density lipoprotein cholesterol (HDL-C) is considered anti-atherogenic good cholesterol. It is involved in reverse transport of lipids. Epidemiological studies have found inverse relationship of HDL-C and coronary heart disease (CHD) risk. When grouped according to HDL-C, subjects having HDL-C more than 60 mg/dL had lesser risk of CHD than those having HDL-C of 40-60 mg/dL, who in turn had lesser risk than those who had HDL-C less than 40 mg/dL. No upper limit for beneficial effect of HDL-C on CHD risk has been identified. The goals of treating patients with low HDL-C have not been firmly established. Though many drugs are known to improve HDL-C concentration, statins are proven to improve CHD risk and mortality. Cholesteryl ester transfer protein (CETP) is involved in metabolism of HDL-C and its inhibitors are actively being screened for clinical utility. However, final answer is still awaited on CETP-inhibitors.
- Subjects
HIGH density lipoproteins; CORONARY disease; HEART disease risk factors; STATINS (Cardiovascular agents); CHOLESTERYL ester transfer protein
- Publication
Indian Journal of Endocrinology & Metabolism, 2012, Vol 16, pS236
- ISSN
2230-8210
- Publication type
Article
- DOI
10.4103/2230-8210.104048