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- Title
Low density lipoproteins may actually be some negative acute phase proteins in the plasma.
- Authors
Helvaci, Mehmet Rami; Abyad, Abdulrazak; Pocock, Lesley
- Abstract
Background: We tried to understand whether or not low density lipoproteins (LDL) may actually be some negative acute phase proteins (APP) in the plasma. Methods: Patients with plasma triglycerides values lower than 100 mg/dL were collected into the first, lower than 150 mg/dL into the second, lower than 200 mg/dL into the third, and 200 mg/dL and higher into the fourth groups, respectively. Results: We studied 457 cases (266 females and 191 males), totally. The male ratio, mean age, body mass index (BMI), fasting plasma glucose (FPG) and prevalences of smoking, white coat hypertension (WCH), hypertension (HT), diabetes mellitus (DM), and chronic obstructive pulmonary disease (COPD) increased parallel to the increased plasma triglycerides values from the first towards the fourth groups, continuously (p<0.05 nearly in all steps). Whereas the mean LDL values increased just up to the plasma triglycerides value of 200 mg/dL and then decreased, significantly (140.9 versus 128.2 mg/dL, p= 0.009). Conclusions: Increased plasma triglycerides values may be one of the most significant parameters of the metabolic syndrome that is characterized with disseminated endothelial damage, inflammation, fibrosis, accelerated atherosclerosis, end-organ insufficiencies, early aging, and premature death. Although the continuously increased male ratio, mean age, BMI, FPG, smoking, WCH, HT, DM, and COPD, parallel to the increased plasma triglycerides values, the mean LDL values increased just up to the plasma triglycerides values of 200 mg/dL and then decreased, significantly. The significant decrease can be explained by the hypothesis that LDL may actually be some negative APP in the plasma.
- Subjects
ACUTE phase proteins; LOW density lipoproteins; BLOOD proteins; OBSTRUCTIVE lung diseases; BODY mass index
- Publication
Middle East Journal of Internal Medicine, 2020, Vol 12, Issue 1, p19
- ISSN
1837-9052
- Publication type
Article
- DOI
10.5742/mejim.2020.93782