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- Title
An Environmentally Sustainable Synthesis of Enantioenriched CF<sub>3</sub>‐Chromanol, Indanol and Tetralol Derivatives by Rh‐Catalyzed Asymmetric Transfer Hydrogenation.
- Authors
Molina Betancourt, Ricardo; Bacheley, Lucas; Karapetyan, Anzhela; Guillamot, Gérard; Phansavath, Phannarath; Ratovelomanana‐Vidal, Virginie
- Abstract
The Rh(III)‐catalyzed asymmetric reduction of α‐trifluoromethyl ketones through transfer hydrogenation was developed under mild conditions to access a series of enantioenriched cis‐trifluoromethyl alcohols via a dynamic kinetic resolution process. The reaction was efficiently performed in the green solvent 2‐MeTHF with HCO2H/Et3N (1 : 1) as the hydrogen source. High yields, alongside excellent diastereo‐ and enantioselectivities were obtained for the synthesis of CF3‐chromanol, CF3‐indanol and CF3‐tetralol derivatives.
- Subjects
HYDROGENATION; TRANSFER hydrogenation; KINETIC resolution; SUSTAINABLE chemistry
- Publication
ChemCatChem, 2022, Vol 14, Issue 15, p1
- ISSN
1867-3880
- Publication type
Article
- DOI
10.1002/cctc.202200595