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- Title
Interleukin-10 production at the early stage of infection with foot-and-mouth disease virus related to the likelihood of persistent infection in cattle.
- Authors
Zhidong Zhang; Doel, Claudia; Bashiruddin, John B.
- Abstract
The factors leading to persistent infection of foot-and-mouth disease (FMD) virus in ruminants are not well defined. This paper provides evidence of the presence of interleukin-10 (IL-10) early in the course of infection (1-4 days) as a factor in the development of persistence of FMD virus in cattle. Results showed that serum IL-10 in carrier cattle infected with FMD virus type O (n = 4) was detected and peaked at 1 or 2 days post infection and rapidly declined thereafter. In contract, serum IL-10 levels in non-carrier cattle (n = 21) were very low or undetectable during the same period.
- Subjects
INTERLEUKIN-10; FOOT &; mouth disease; VIRUS diseases; CATTLE as carriers of disease; BLOOD serum analysis
- Publication
Veterinary Research, 2015, Vol 46, p1
- ISSN
0928-4249
- Publication type
Article
- DOI
10.1186/s13567-015-0276-y