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- Title
Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases.
- Authors
Rahbari, Nuh N.; Kedrin, Dmitriy; Incio, Joao; Hao Liu; Ho, William W.; Nia, Hadi T.; Edrich, Christina M.; Keehoon Jung; Daubriac, Julien; Ivy Chen; Takahiro Heishi; Martin, John D.; Yuhui Huang; Maimon, Nir; Reissfelder, Christoph; Weitz, Jurgen; Boucher, Yves; Clark, Jeffrey W.; Grodzinsky, Alan J.; Duda, Dan G.
- Abstract
The article presents a study which examined the effects of antiangiogenic or anti-vascular endothelial growth factor (VEGF) therapy on the composition of both collagenous and noncollagenous extracellular matrix (ECM), as well as blood perfusion as mechanisms of acquired resistance to antiangiogenic therapy in liver metastatic colorectal cancer (mCRC). Also cited are the effects of anti-VEGF therapy on the physical properties of colorectal liver metastases.
- Subjects
COLON cancer treatment; VASCULAR endothelial growth factor antagonists; EXTRACELLULAR matrix; LIVER metastasis; LIVER cancer; THERAPEUTICS
- Publication
Science Translational Medicine, 2016, Vol 8, Issue 360, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aaf5219