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In-depth Characterization of Vaccine Breakthrough Infections With SARS-CoV-2 Among Health Care Workers in a Dutch Academic Medical Center.
Published in:
Open Forum Infectious Diseases, 2022, v. 9, n. 1, p. 1, doi. 10.1093/ofid/ofab553
By:
- Rümke, Lidewij W;
- Groenveld, Femke C;
- Os, Yvonne M G van;
- Praest, Patrique;
- Tanja, Anniek A N;
- Jong, Dorien T C M de;
- Symons, Jori;
- Schuurman, Rob;
- Reinders, Tessa;
- Hofstra, L Marije;
- Nierkens, Stefan;
- Thijsen, Steven F T;
- Heron, Michiel;
- Lebbink, Robert-Jan;
- Beekman, Jeffrey M;
- Nijhuis, Monique;
- Wensing, Annemarie M J
Publication type:
Article
Drug Repurposing for Cystic Fibrosis: Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids.
Published in:
International Journal of Molecular Sciences, 2022, v. 23, n. 20, p. 12657, doi. 10.3390/ijms232012657
By:
- Rodenburg, Lisa W.;
- Delpiano, Livia;
- Railean, Violeta;
- Centeio, Raquel;
- Pinto, Madalena C.;
- Smits, Shannon M. A.;
- van der Windt, Isabelle S.;
- van Hugten, Casper F. J.;
- van Beuningen, Sam F. B.;
- Rodenburg, Remco N. P.;
- van der Ent, Cornelis K.;
- Amaral, Margarida D.;
- Kunzelmann, Karl;
- Gray, Michael A.;
- Beekman, Jeffrey M.;
- Amatngalim, Gimano D.
Publication type:
Article
A frameshift polymorphism in P2X5 elicits an allogeneic cytotoxic T lymphocyte response associated with remission of chronic myeloid leukemia.
Published in:
Journal of Clinical Investigation, 2005, v. 115, n. 12, p. 3506, doi. 10.1172/JCI24832
By:
- de Rijke, Björn;
- van Horssen-Zoetbrood, Agnes;
- Beekman, Jeffrey M.;
- Otterud, Britt;
- Maas, Frans;
- Woestenenk, Rob;
- Kester, Michel;
- Leppert, Mark;
- Schattenberg, Anton V.;
- Witte, Theo de;
- van de Wiel-van Kemenade, Elly;
- Dolstra, Harry
Publication type:
Article
A new era for people with cystic fibrosis.
Published in:
2021
By:
- Bierlaagh, Marlou C.;
- Muilwijk, Danya;
- Beekman, Jeffrey M.;
- van der Ent, Cornelis K.
Publication type:
journal article
A functional CFTR assay using primary cystic fibrosis intestinal organoids.
Published in:
Nature Medicine, 2013, v. 19, n. 7, p. 939, doi. 10.1038/nm.3201
By:
- Dekkers, Johanna F;
- Wiegerinck, Caroline L;
- de Jonge, Hugo R;
- Bronsveld, Inez;
- Janssens, Hettie M;
- de Winter-de Groot, Karin M;
- Brandsma, Arianne M;
- de Jong, Nienke W M;
- Bijvelds, Marcel J C;
- Scholte, Bob J;
- Nieuwenhuis, Edward E S;
- van den Brink, Stieneke;
- Clevers, Hans;
- van der Ent, Cornelis K;
- Middendorp, Sabine;
- Beekman, Jeffrey M
Publication type:
Article
An open-source high-content analysis workflow for CFTR function measurements using the forskolin-induced swelling assay.
Published in:
Bioinformatics, 2020, v. 36, n. 24, p. 5686, doi. 10.1093/bioinformatics/btaa1073
By:
- Hagemeijer, Marne C;
- Vonk, Annelotte M;
- Awatade, Nikhil T;
- Silva, Iris A L;
- Tischer, Christian;
- Hilsenstein, Volker;
- Beekman, Jeffrey M;
- Amaral, Margarida D;
- Botelho, Hugo M
Publication type:
Article
Effect of Long-Term Voluntary Exercise Wheel Running on Susceptibility to Bacterial Pulmonary Infections in a Mouse Model.
Published in:
PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0082869
By:
- van de Weert – van Leeuwen, Pauline B.;
- de Vrankrijker, Angélica M. M.;
- Fentz, Joachim;
- Ciofu, Oana;
- Wojtaszewski, Jørgen F. P.;
- Arets, Hubertus G. M.;
- Hulzebos, Hendrikus J.;
- van der Ent, Cornelis K.;
- Beekman, Jeffrey M.;
- Johansen, Helle K.
Publication type:
Article
STAT3 Regulates Monocyte TNF-Alpha Production in Systemic Inflammation Caused by Cardiac Surgery with Cardiopulmonary Bypass.
Published in:
PLoS ONE, 2012, v. 7, n. 4, p. 1, doi. 10.1371/journal.pone.0035070
By:
- Jong, Petrus R. de;
- Schadenberg, Alvin W. L.;
- van den Broek, Theo;
- Beekman, Jeffrey M.;
- van Wijk, Femke;
- Coffer, Paul J.;
- Prakken, Berent J.;
- Jansen, Nicolaas J. G.
Publication type:
Article
CFTR Expression Analysis in Human Nasal Epithelial Cells by Flow Cytometry.
Published in:
PLoS ONE, 2011, v. 6, n. 12, p. 1, doi. 10.1371/journal.pone.0027658
By:
- van Meegen, Marit A.;
- Terheggen-Lagro, Suzanne W. J.;
- van der Ent, Cornelis K.;
- Beekman, Jeffrey M.
Publication type:
Article
Human Regulatory T Cell Suppressive Function Is Independent of Apoptosis Induction in Activated Effector T Cells.
Published in:
PLoS ONE, 2009, v. 4, n. 9, p. 1, doi. 10.1371/journal.pone.0007183
By:
- Vercoulen, Yvonne;
- Wehrens, Ellen J.;
- van Teijlingen, Nienke H.;
- de Jager, Wilco;
- Beekman, Jeffrey M.;
- Prakken, Berent J.
Publication type:
Article
Comparison of Organoid Swelling and Biomarkers of CFTR Function to Determine Effects of Lumacaftor-Ivacaftor in Patients with Cystic Fibrosis Homozygous for the F508del Mutation.
Published in:
2020
By:
- Graeber, Simon Y.;
- van Mourik, Peter;
- Vonk, Annelotte M.;
- Kruisselbrink, Evelien;
- Hirtz, Stephanie;
- van der Ent, Cornelis K.;
- Mall, Marcus A.;
- Beekman, Jeffrey M
Publication type:
research
rAAV-CFTRΔR rescues the cystic fibrosis phenotype in human intestinal organoids and CF mice.
Published in:
American Journal of Respiratory & Critical Care Medicine, 2016, v. 193, n. 3, p. E1, doi. 10.1164/rccm.201505-0914oc
By:
- Vidović, Dragana;
- Carlon, Marianne S.;
- da Cunha, Mélanie F.;
- Dekkers, Johanna F.;
- Hollenhorst, Monika I.;
- Bijvelds, Marcel J. C.;
- Ramalho, Anabela S.;
- Van den Haute, Chris;
- Ferrante, Marc;
- Baekelandt, Veerle;
- Janssens, Hettie M.;
- De Boeck, Kris;
- Sermet-Gaudelus, Isabelle;
- de Jonge, Hugo R.;
- Gijsbers, Rik;
- Beekman, Jeffrey M.;
- Edelman, Aleksander;
- Debyser, Zeger
Publication type:
Article
rAAV-CFTRΔR Rescues the Cystic Fibrosis Phenotype in Human Intestinal Organoids and Cystic Fibrosis Mice.
Published in:
2016
By:
- Vidović, Dragana;
- Carlon, Marianne S.;
- da Cunha, Mélanie F.;
- Dekkers, Johanna F.;
- Hollenhorst, Monika I.;
- Bijvelds, Marcel J. C.;
- Ramalho, Anabela S.;
- Van den Haute, Chris;
- Ferrante, Marc;
- Baekelandt, Veerle;
- Janssens, Hettie M.;
- De Boeck, Kris;
- Sermet-Gaudelus, Isabelle;
- de Jonge, Hugo R.;
- Gijsbers, Rik;
- Beekman, Jeffrey M.;
- Edelman, Aleksander;
- Debyser, Zeger
Publication type:
journal article
A novel fluorescent sensor for measurement of CFTR function by flow cytometry.
Published in:
Cytometry. Part A, 2013, v. 83A, n. 6, p. 576, doi. 10.1002/cyto.a.22275
By:
- Vijftigschild, Lodewijk A. W.;
- van der Ent, Cornelis K.;
- Beekman, Jeffrey M.
Publication type:
Article
Optimal Complement-Mediated Phagocytosis of Pseudomonas aeruginosa by Monocytes Is Cystic Fibrosis Transmembrane Conductance Regulator-Dependent.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2013, v. 49, n. 3, p. 463, doi. 10.1165/rcmb.2012-0502OC
By:
- Van de Weert-van Leeuwen, Pauline B.;
- Van Meegen, Marit A.;
- Speirs, Jennifer J.;
- Pals, D. J.;
- Rooijakkers, Suzan H. M.;
- Van der Ent, Cornelis K.;
- Terheggen-Lagro, Suzanne W. J.;
- Arets, Hubertus G. M.;
- Beekman, Jeffrey M.
Publication type:
Article
Validating organoid-derived human intestinal monolayers for personalized therapy in cystic fibrosis.
Published in:
Life Science Alliance, 2023, v. 6, n. 6, p. 1, doi. 10.26508/lsa.202201857
By:
- Birimberg-Schwartz, Liron;
- Ip, Wan;
- Bartlett, Claire;
- Avolio, Julie;
- Vonk, Annelotte M.;
- Gunawardena, Tarini;
- Kai Du;
- Esmaeili, Mohsen;
- Beekman, Jeffrey M.;
- Rommens, Johanna;
- Strug, Lisa;
- Bear, Christine E.;
- Moraes, Theo J.;
- Gonska, Tanja
Publication type:
Article
Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids.
Published in:
Life Science Alliance, 2021, v. 4, n. 10, p. 1, doi. 10.26508/lsa.202000940
By:
- Geurts, Maarten H.;
- de Poel, Eyleen;
- Pleguezuelos-Manzano, Cayetano;
- Oka, Rurika;
- Carrillo, Leo;
- Andersson-Rolf, Amanda;
- Boretto, Matteo;
- Brunsveld, Jesse E.;
- van Boxtel, Ruben;
- Beekman, Jeffrey M.;
- Clevers, Hans
Publication type:
Article
Rationale and design of the HIT-CF organoid study: stratifying cystic fibrosis patients based on intestinal organoid response to different CFTR-modulators.
Published in:
Translational Medicine Communications, 2020, v. 5, n. 1, p. 1, doi. 10.1186/s41231-020-00060-3
By:
- van Mourik, Peter;
- Michel, Sabine;
- Vonk, Annelotte M.;
- Beekman, Jeffrey M.;
- van der Ent, Cornelis K.;
- on behalf of the HIT-CF consortium;
- De Keyser, Hilde;
- Lammertyn, Elise;
- van Koningsbruggen-Rietschel, Silke;
- Naehrlich, Lutz;
- Pool, Judith;
- van de Craen, Marc;
- Aguilera, Begoña;
- Pott, Johanna;
- Vries, Rob G. J.;
- Boj, Sylvia F.;
- De Boeck, Kris;
- Vermeulen, François;
- Ramalho, Anabela S.;
- Silva, Iris A. L.
Publication type:
Article
Impaired SARS-CoV-2 specific T-cell response in patients with severe COVID-19.
Published in:
Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1046639
By:
- Rümke, Lidewij W.;
- Smit, Wouter L.;
- Bossink, Ailko;
- Limonard, Gijs J. M.;
- Muilwijk, Danya;
- Haas, Lenneke E. M.;
- Reusken, Chantal;
- van der Wal, Sanne;
- Thio, Bing J.;
- van Os, Yvonne M. G.;
- Gremmels, Hendrik;
- Beekman, Jeffrey M.;
- Nijhuis, Monique;
- Wensing, Annemarie M. J.;
- Heron, Michiel;
- Thijsen, Steven F. T.
Publication type:
Article
The SLC26A9 inhibitor S9‐A13 provides no evidence for a role of SLC26A9 in airway chloride secretion but suggests a contribution to regulation of ASL pH and gastric proton secretion.
Published in:
FASEB Journal, 2022, v. 36, n. 11, p. 1, doi. 10.1096/fj.202200313RR
By:
- Jo, Sungwoo;
- Centeio, Raquel;
- Park, Jinhong;
- Ousingsawat, Jiraporn;
- Jeon, Dong‐kyu;
- Talbi, Khaoula;
- Schreiber, Rainer;
- Ryu, Kunhi;
- Kahlenberg, Kristin;
- Somoza, Veronika;
- Delpiano, Livia;
- Gray, Michael A.;
- Amaral, Margarida D.;
- Railean, Violeta;
- Beekman, Jeffrey M.;
- Rodenburg, Lisa W.;
- Namkung, Wan;
- Kunzelmann, Karl
Publication type:
Article
Airway Epithelial Cultures of Children with Esophageal Atresia as a Model to Study Respiratory Tract Disorders.
Published in:
Children, 2023, v. 10, n. 6, p. 1020, doi. 10.3390/children10061020
By:
- Dreyer, Henriette H. M.;
- van Tuyll van Serooskerken, Eleonora Sofie;
- Rodenburg, Lisa W.;
- Bittermann, Arnold J. N.;
- Arets, Hubertus G. M.;
- Reuling, Ellen M. B. P.;
- Verweij, Johannes W.;
- Haarman, Eric G.;
- van der Zee, David C.;
- Tytgat, Stefaan H. A. J.;
- van der Ent, Cornelis K.;
- Beekman, Jeffrey M.;
- Amatngalim, Gimano D.;
- Lindeboom, Maud Y. A.
Publication type:
Article
Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis.
Published in:
Science Translational Medicine, 2016, v. 8, n. 344, p. 1, doi. 10.1126/scitranslmed.aad8278
By:
- Dekkers, Johanna F.;
- Berkers, Gitte;
- Kruisselbrink, Evelien;
- Vonk, Annelotte;
- de Jonge, Hugo R.;
- Janssens, Hettie M.;
- Bronsveld, Inez;
- van de Graaf, Eduard A.;
- Nieuwenhuis, Edward E. S.;
- Houwen, Roderick H. J.;
- Vleggaar, Frank P.;
- Escher, Johanna C.;
- de Rijke, Yolanda B.;
- Majoor, Christof J.;
- Heijerman, Harry G. M.;
- de Winter–de Groot, Karin M.;
- Clevers, Hans;
- van der Ent, Cornelis K.;
- Beekman, Jeffrey M.
Publication type:
Article
Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding.
Published in:
PLoS Biology, 2014, v. 12, n. 11, p. 1, doi. 10.1371/journal.pbio.1001998
By:
- Roth, Daniela Martino;
- Hutt, Darren M.;
- Tong, Jiansong;
- Bouchecareilh, Marion;
- Wang, Ning;
- Seeley, Theo;
- Dekkers, Johanna F.;
- Beekman, Jeffrey M.;
- Garza, Dan;
- Drew, Lawrence;
- Masliah, Eliezer;
- Morimoto, Richard I.;
- Balch, William E.
Publication type:
Article
OrgaSegment: deep-learning based organoid segmentation to quantify CFTR dependent fluid secretion.
Published in:
Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-05966-4
By:
- Lefferts, Juliet W.;
- Kroes, Suzanne;
- Smith, Matthew B.;
- Niemöller, Paul J.;
- Nieuwenhuijze, Natascha D. A.;
- Sonneveld van Kooten, Heleen N.;
- van der Ent, Cornelis K.;
- Beekman, Jeffrey M.;
- van Beuningen, Sam F. B.
Publication type:
Article
High-resolution 3D imaging of fixed and cleared organoids.
Published in:
Nature Protocols, 2019, v. 14, n. 6, p. 1756, doi. 10.1038/s41596-019-0160-8
By:
- Dekkers, Johanna F.;
- Alieva, Maria;
- Wellens, Lianne M.;
- Ariese, Hendrikus C. R.;
- Jamieson, Paul R.;
- Vonk, Annelotte M.;
- Amatngalim, Gimano D.;
- Hu, Huili;
- Oost, Koen C.;
- Snippert, Hugo J. G.;
- Beekman, Jeffrey M.;
- Wehrens, Ellen J.;
- Visvader, Jane E.;
- Clevers, Hans;
- Rios, Anne C.
Publication type:
Article
Recurrent Respiratory Syncytial Virus Infection in a CD14-Deficient Patient.
Published in:
2022
By:
- Besteman, Sjanna B;
- Phung, Emily;
- Raeven, Henriette H M;
- Amatngalim, Gimano D;
- Rumpret, Matevž;
- Crabtree, Juliet;
- Schepp, Rutger M;
- Rodenburg, Lisa W;
- Siemonsma, Susanna G;
- Verleur, Nile;
- Slooten, Rianne van;
- Duran, Karen;
- Haaften, Gijs W van;
- Beekman, Jeffrey M;
- Chang, Lauren A;
- Meyaard, Linde;
- van der Bruggen, Tjomme;
- Berbers, Guy A M;
- Derksen, Nicole;
- Nierkens, Stefan
Publication type:
journal article
Mechanism-based corrector combination restores ΔF508-CFTR folding and function.
Published in:
Nature Chemical Biology, 2013, v. 9, n. 7, p. 444, doi. 10.1038/nchembio.1253
By:
- Okiyoneda, Tsukasa;
- Veit, Guido;
- Dekkers, Johanna F;
- Bagdany, Miklos;
- Soya, Naoto;
- Xu, Haijin;
- Roldan, Ariel;
- Verkman, Alan S;
- Kurth, Mark;
- Simon, Agnes;
- Hegedus, Tamas;
- Beekman, Jeffrey M;
- Lukacs, Gergely L
Publication type:
Article
CFTR Function Restoration upon Elexacaftor/Tezacaftor/Ivacaftor Treatment in Patient-Derived Intestinal Organoids with Rare CFTR Genotypes.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 19, p. 14539, doi. 10.3390/ijms241914539
By:
- Lefferts, Juliet W.;
- Bierlaagh, Marlou C.;
- Kroes, Suzanne;
- Nieuwenhuijze, Natascha D. A.;
- Sonneveld van Kooten, Heleen N.;
- Niemöller, Paul J.;
- Verburg, Tibo F.;
- Janssens, Hettie M.;
- Muilwijk, Danya;
- van Beuningen, Sam F. B.;
- van der Ent, Cornelis K.;
- Beekman, Jeffrey M.
Publication type:
Article
Exploring intrinsic variability between cultured nasal and bronchial epithelia in cystic fibrosis.
Published in:
Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-45201-4
By:
- Rodenburg, Lisa W.;
- Metzemaekers, Mieke;
- van der Windt, Isabelle S.;
- Smits, Shannon M. A.;
- den Hertog-Oosterhoff, Loes A.;
- Kruisselbrink, Evelien;
- Brunsveld, Jesse E.;
- Michel, Sabine;
- de Winter-de Groot, Karin M.;
- van der Ent, Cornelis K.;
- Stadhouders, Ralph;
- Beekman, Jeffrey M.;
- Amatngalim, Gimano D.
Publication type:
Article

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