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- Title
Magnetic resonance elastography in evaluation of liver fibrosis in children with chronic liver disease.
- Authors
Demirtaş, Duygu; Ünal, Emre; İdilman, İlkay S.; Akçören, Zuhal; Göktaş, Mehmet Akif; Boyraz, Meryem Seda; Karahan, Sevilay; Orhan, Diclehan; Haliloğlu, Mithat; Karçaaltıncaba, Muşturay; Özen, Hasan
- Abstract
Background: Magnetic resonance elastography (MRE) has been used to stage liver fibrosis in adults. We aimed to assess the agreement between the Ishak scoring system and magnetic resonance elastography-measured liver stiffness (MRE-LS) in children. This study included all the children who underwent abdominal MRE and liver biopsies between February 2018 and January 2021. The correlation between MRE-LS and Ishak fibrosis stage, MRE parameters, and clinical and biochemical markers affecting this relationship was investigated. Results: A total of 52 patients (31 male; a median age of 11.8 years) were included in the study. The MRE-LS values were significantly different between Ishak fibrosis stages (p = 0.036). With a cut-off value of 2.97 kilopascals, MRE-LS had sensitivity, specificity, PPV, NPV and accuracy values of 90.9%, 82.9%, 58.8%, 97.1%, and 84.6%, respectively, for differentiating mild/moderate fibrosis (F0, 1, 2, 3) from severe fibrosis (F ≥ 4). Although MRE-LS was moderately correlated with Ishak fibrosis score and histological activity index and weakly correlated with aspartate aminotransferase, hepatic steatosis, and R2*, only Ishak fibrosis score was a significant predictor of MRE-LS. MRE-measured spleen stiffness was weakly correlated with the Ishak fibrosis score. Conclusions: MRE has high sensitivity and specificity for evaluating liver fibrosis in children. MRE may be used to evaluate liver fibrosis in pediatric patients. Key points: MRE has high sensitivity and specificity in evaluating liver fibrosis in children. MRE-LS is significantly correlated with histological Ishak fibrosis stage. Comparing to other parameters, only MRE-LS is a predictor of fibrosis stage. In the future, MRE may replace biopsy to evaluate liver fibrosis.
- Subjects
HEPATIC fibrosis; MAGNETIC resonance; LIVER diseases; CHRONIC diseases; ELASTOGRAPHY; FATTY liver
- Publication
Insights into Imaging, 2023, Vol 14, Issue 1, p1
- ISSN
1869-4101
- Publication type
Article
- DOI
10.1186/s13244-023-01390-0