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- Title
Tracing human papillomavirus in skin and mucosal squamous cell carcinoma: a histopathological retrospective survey.
- Authors
Nili, Ali; Daneshpazhooh, Maryam; Mahmoudi, Hamidreza; Kamyab, Kambiz; Jamshidi, Shirin Taraz; Soleiman-Meigooni, Saeed; Darvishi, Mohammad
- Abstract
Worldwide, squamous cell carcinoma (SCC) incidence is rising. The literature debates the human papillomavirus (HPV)'s role in cutaneous SCC development. We examined HPV histopathology in SCC samples in this study. Retrospective study at tertiary referral skin center in 2020. Histopathological features of HPV, including koilocytosis, hyperkeratosis, acanthosis, hypergranulosis, parakeratosis, solar elastosis, papillomatosis, and tumor grade, were examined in SCC specimens. Two dermatopathologists independently reevaluated all samples. We examined 331 SCC cases (male:female ratio = 3.9:1). The mean age was 68.1, with 15.1 standard deviation. Lesions were most common on the face (40.5%), scalp (22.7%), and extremities (20.8%). Koilocytes were found in 50 (15.1%) lesions. Nail (38.1%, p=0.007), oral cavity (36.8%, p=0.014), and genitalia (60.0%, p=0.026) lesions had higher koilocytosis rates. SCCs were found in 6.6% of specimens, but in situ tumors had the highest koilocytosis (64.7%), significantly higher than other grades (p<0.001). SCC pathology often shows HPV and specific koilocyte histopathology. Well-differentiated SCC has a stronger association with nail, oral, and genital lesions.
- Subjects
HUMAN papillomavirus; SQUAMOUS cell carcinoma; HISTOPATHOLOGY; TUMOR grading; STANDARD deviations
- Publication
Dermatology Reports, 2024, Vol 16, Issue 2, pN.PAG
- ISSN
2036-7406
- Publication type
Article
- DOI
10.4081/dr.2024.9833