We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association of serum leptin levels with progression of diabetic kidney disease in patients with type 2 diabetes.
- Authors
Hanai K; Babazono T; Mugishima M; Yoshida N; Nyumura I; Toya K; Bouchi R; Tanaka N; Uchigata Y; Hanai, Ko; Babazono, Tetsuya; Mugishima, Michino; Yoshida, Naoshi; Nyumura, Izumi; Toya, Kiwako; Bouchi, Ryotaro; Tanaka, Nobue; Uchigata, Yasuko
- Abstract
<bold>Objective: </bold>To clarify the association of serum leptin levels with progression of diabetic kidney disease in patients with type 2 diabetes (T2D).<bold>Research Design and Methods: </bold>This was an observational cohort study of 668 patients with T2D. Patients were classified into three groups by sex-specific tertile of leptin levels. Outcome measurements were the rate of change in estimated glomerular filtration rate (eGFR) and progression to a more advanced stage of albuminuria.<bold>Results: </bold>Patients with low or high leptin levels had a steeper eGFR decline (-2.07 and -2.14 mL/min/1.73 m(2)/year) than those with midrange leptin levels (-0.82 mL/min/1.73 m(2)/year; P < 0.01), whereas patients with low leptin levels had an elevated risk of progression of albuminuria as compared with those with high leptin levels (hazard ratio 3.125 [95% CI 1.302-7.499]).<bold>Conclusions: </bold>Both low and high serum leptin levels were risk factors for kidney function decline. Meanwhile, lower serum leptin levels were associated with progression of albuminuria.
- Publication
Diabetes Care, 2011, Vol 34, Issue 12, p2557
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc11-1039