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- Title
Mixed Results for Bone Marrow-Derived Cell Therapy for Ischemic Heart Disease.
- Authors
Marbân, Eduardo; Malliaras, Konstantinos
- Abstract
The authors discuss the effect of bone marrow-derived cell therapy on safety and substitute end points in the patients after myocardial infarction (MI). They discuss two early phase studies including the Timing In Myocardial infarction Evaluation (TIME) trial and the POSEIDON trial. 120 patients with acute MI and autologous mononuclear cells (MNCs) were examined in the placebo controlled TIME trial.
- Subjects
MYOCARDIAL infarction; B cells; CLINICAL trials; PLACEBOS; CORONARY disease
- Publication
JAMA: Journal of the American Medical Association, 2012, Vol 308, Issue 22, p2405
- ISSN
0098-7484
- Publication type
Editorial
- DOI
10.1001/jama.2012.64751