We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Diagnosis, microbial epidemiology, and antibiotic treatment of acute otitis media in children: a systematic review.
- Authors
Coker TR; Chan LS; Newberry SJ; Limbos MA; Suttorp MJ; Shekelle PG; Takata GS; Coker, Tumaini R; Chan, Linda S; Newberry, Sydne J; Limbos, Mary Ann; Suttorp, Marika J; Shekelle, Paul G; Takata, Glenn S
- Abstract
<bold>Context: </bold>Acute otitis media (AOM) is the most common condition for which antibiotics are prescribed for US children; however, wide variation exists in diagnosis and treatment.<bold>Objectives: </bold>To perform a systematic review on AOM diagnosis, treatment, and the association of heptavalent pneumococcal conjugate vaccine (PCV7) use with AOM microbiology.<bold>Data Sources: </bold>PubMed, Cochrane Databases, and Web of Science, searched to identify articles published from January 1999 through July 2010.<bold>Study Selection: </bold>Diagnostic studies with a criterion standard, observational studies and randomized controlled trials comparing AOM microbiology with and without PCV7, and randomized controlled trials assessing antibiotic treatment.<bold>Data Extraction: </bold>Independent article review and study quality assessment by 2 investigators with consensus resolution of discrepancies.<bold>Results: </bold>Of 8945 citations screened, 135 were included. Meta-analysis was performed for comparisons with 3 or more trials. Few studies examined diagnosis; otoscopic findings of tympanic membrane bulging (positive likelihood ratio, 51 [95% confidence interval {CI}, 36-73]) and redness (positive likelihood ratio, 8.4 [95% CI, 7-11]) were associated with accurate diagnosis. In the few available studies, prevalence of Streptococcus pneumoniae decreased (eg, 33%-48% vs 23%-31% of AOM isolates), while that of Haemophilus influenzae increased (41%-43% vs 56%-57%) pre- vs post-PCV7. Short-term clinical success was higher for immediate use of ampicillin or amoxicillin vs placebo (73% vs 60%; pooled rate difference, 12% [95% CI, 5%-18%]; number needed to treat, 9 [95% CI, 6-20]), while increasing the rate of rash or diarrhea by 3% to 5%. Two of 4 studies showed greater clinical success for immediate vs delayed antibiotics (95% vs 80%; rate difference, 15% [95% CI, 6%-24%] and 86% vs 70%; rate difference, 16% [95% CI, 6%-26%]). Data are absent on long-term effects on antimicrobial resistance. Meta-analyses in general showed no significant differences in antibiotic comparative effectiveness.<bold>Conclusions: </bold>Otoscopic findings are critical to accurate AOM diagnosis. AOM microbiology has changed with use of PCV7. Antibiotics are modestly more effective than no treatment but cause adverse effects in 4% to 10% of children. Most antibiotics have comparable clinical success.
- Publication
JAMA: Journal of the American Medical Association, 2010, Vol 304, Issue 19, p2161
- ISSN
0098-7484
- Publication type
journal article
- DOI
10.1001/jama.2010.1651