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- Title
Inflammation markers and metabolic characteristics of subjects with 1-h plasma glucose levels.
- Authors
Bardini G; Dicembrini I; Cresci B; Rotella CM; Bardini, Gianluca; Dicembrini, Ilaria; Cresci, Barbara; Rotella, Carlo Maria
- Abstract
<bold>Objective: </bold>To assess the association of 1-h plasma glucose (1hPG) and inflammation with normal glucose tolerance (NGT) and pre-diabetes.<bold>Research Design and Methods: </bold>A cohort of 1,062 subjects was enrolled. After oral glucose load (oral glucose tolerance test), we compared subjects with NGT and pre-diabetes above and below the 1hPG cut point (155 mg/dl). Fibrinogen and leukocytes count (white blood cells [WBCs]) for subclinical inflammation, lipid ratios, insulin sensitivity (Matsuda index) were determined.<bold>Results: </bold>Patients with NGT and pre-diabetes (1hPG >155 mg/dl) showed a significant increase of inflammatory markers and lipid ratios (for all, P < 0.05). In age-, sex-, and BMI-adjusted analysis, 1hPG was associated with a significantly higher WBC count and fibrinogen (P < 0.05). Patients with elevated 1hPG showed a highly significant lower insulin sensitivity than subjects <1hPG (P < 0.01).<bold>Conclusions: </bold>Elevated 1hPG in subjects with NGT and pre-diabetes is associated with subclinical inflammation, high lipid ratios, and insulin resistance. Therefore, 1hPG >155 mg/dl could be considered a new "marker" for cardiovascular risk.
- Publication
Diabetes Care, 2010, Vol 33, Issue 2, p411
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc09-1342