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- Title
The Effect of Curcumin on HDL Cholesterol Uptake Capacity in Obese Individuals: A Randomized Double Blinded Cross over Clinical Trial.
- Authors
Saberi-Karimian, Maryam; Nosrati, Mina; Aghasizadeh, Malihe; Ghayour-Mobarhan, Majid
- Abstract
Background: The obesity prevalence has augmented in adults globally over the past 3 decades. Obesity is a common risk factor associated with cardiovascular disease (CVD) risk. Curcumin has been reported to exert positive effects on lipid metabolism, including HDL functionality. We have evaluated the effects of curcumin on HDL cholesterol uptake capacity in subjects with obesity. Methods: This study was a randomized double blinded cross over clinical trial approved by the Mashhad University of Medical Sciences (ID: 960443). 30 obese individuals received curcumin and placebo (1 g per day for 30 days). The subjects were crossed over to the alternative regimen after a 2 week wash-out period. A modified cholesterol uptake capacity assay was applied to detect serum HDL Cholesterol Uptake Capacity. Results: There were no significant differences in baseline features of two study groups (P-value> 0.05). As well, we did not observe any significant effect of curcumin on serum HDL cholesterol uptake capacity levels in two study groups (Pvalue >0.05). Conclusion: Curcumin supplementation at a dose of 1 g per day for 30 days can not improve HDL CUC in obese individuals.
- Subjects
CARDIOVASCULAR diseases risk factors; CURCUMIN; CLINICAL trials; HDL cholesterol; DIETARY supplements; METABOLIC syndrome
- Publication
Journal of Nutrition, Fasting & Health, 2022, Vol 10, p262
- ISSN
2821-2746
- Publication type
Article