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- Title
The role of herbal medicine and phytochemicals in inhibition of NLRP3 inflammasome: a comprehensive review.
- Authors
Shojaei, Mehrnaz; Khedmatgozar, Hamed; Askari, Gholamreza; Sahebkar, Amirhossein; Bagherniya, Mohammad
- Abstract
The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome is a multiprotein complex that induces caspase-1 activation and the downstream substrates involved with the processing and secretion of the proinflammatory cytokines interleukin-1β (IL-1β) and IL-18 and tumor necrosis factor-α (TNF-α). The NLRP3 inflammasome is activated by a wide range of danger signals that derive from metabolic dysregulation. It has been shown that nutraceuticals and medicinal plants have antiinflammatory properties and could be used as complementary therapy in the treatment of several chronic diseases that are related to inflammation. Herb-based medicine has demonstrated protective effects against NLRP3 inflammasome activation. Therefore, this review focuses on the effects of medicinal plants on NLRP3 inflammasome activation. A comprehensive search was conducted on online medical databases including PubMed, Scopus, and Web of Sciences from inception to September 2021 without any limitations for language. With regard to the fact that there is no approved drug to control or suppress the excessive activation of the inflammasome, this review has identified various herbal bioactive compounds that can potentially improve immunity-related disorders with an acceptable safety profile. Finding of the current study indicated that nutraceuticals and medicinal plants including curcumin, resveratrol, red ginseng, berberine, propolis, arctigenin, silymarin, quercetin, genistein, and catechin can dramatically reduce activation of the NLRP3 inflammasome and subsequently reduce the levels of other inflammatory factors, such as cytokines. Herb-based, natural products/compounds can be considered novel, practical, and accessible agents in chronic inflammatory diseases by inhibiting NLRP3 inflammasome activation.
- Subjects
HERBAL medicine; PHYTOCHEMICALS; INFLAMMASOMES; TUMOR necrosis factors; INTERLEUKIN-18
- Publication
Journal of Nutrition, Fasting & Health, 2022, Vol 10, p223
- ISSN
2821-2746
- Publication type
Article