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- Title
Motor and emotional behavior in experimentally induced depression.
- Authors
Puiu, Maria G.; Manea, Mihnea C.; Manea, Mirela; Tache, Simona
- Abstract
Background. Sleep changes are frequently associated with type 2 diabetes mellitus, obesity and arterial hypertension, and are correlated with major depressive and metabolic disorders. Aims. We aimed to experimentally study in non-obese and obese female rats the following: depression induced by moderate chronic stress, sleep deprivation, olfactory bulbectomy; the influence of obesity on depression by sleep deprivation; changes in motor and emotional behavior in animals with depression. Methods. The research was performed in 4 groups (n=10 animals/group), as follows: group I - control group; group II - with depression by sleep deprivation, induced by sound stimuli; group III - female rats with depression induced by olfactory bulbectomy; group IV - female rats with obesity (by administration of 3 ml fat/day by oropharyngeal gavage; the fat lipid content was 93%), and depression by sleep deprivation. Depression by sleep deprivation was induced by exposure for 120 minutes/24 hours (5 minutes/hour, respectively) to a continuous sound stimulus automatically generated by a bell: 5 dB - original model) and using the Kelly method by bilateral olfactory bulbectomy. Involuntary motility was tested using the open field test. The examination moments were: day 1 and day 28. Statistical processing was performed using the Excel application (Microsoft Office 2007) and the StatsDirect v. 2.7.2. program. Results. The open field test values - emotional score, taking into consideration all groups, evidenced very statistically significant differences between at least two groups, both at moment T0 (p=0.0078) and at moment T28 (p=0.0049). The open field test values - motility score, taking into consideration all groups, showed highly statistically significant differences between at least two groups, both at moment T0 and at moment T28 (p<0.0001). Conclusions. Emotional behavior decreases after depression induced by sleep deprivation and olfactory bulbectomy, compared to controls. Involuntary motor behavior increases in all groups with depression, compared to initial values.
- Subjects
TYPE 2 diabetes; MENTAL depression; SLEEP; HYPERTENSION; METABOLIC disorders; SLEEP deprivation; PSYCHOLOGICAL stress
- Publication
Palestrica of the Third Millennium Civilization & Sport, 2014, Vol 15, Issue 2, p103
- ISSN
1582-1943
- Publication type
Article