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- Title
Impact of Pre-Procedural Fasting Blood Glucose on Long-Term Outcomes of Radiofrequency Catheter Ablation for Atrial Fibrillation in Patients with Diabetes Mellitus.
- Authors
Asfour, Issa; Torlapati, Geeta; Mohanty, Sanghamitra; Della Rocca, Domenico G.; La Fazia, Vincenzo Mirco; MacDonald, Bryan C.; Mayedo, Angel Quintero; Gianni, Carola; Burkhard, J. David; Bassiouny, Mohamed A.; Gallinghouse, G. Joseph; Horton, Rodney P.; Al-Ahmad, Amin; Natale, Andrea
- Abstract
Introduction: Diabetes mellitus (DM) is known to be an independent risk factor for atrial fibrillation (AF). This study investigates the impact of fasting blood glucose control on the long-term outcomes of radiofrequency catheter ablation for AF in patients with DM. Methods: Consecutive patients with DM and undergoing first-time AF radiofrequency catheter ablation in our center were included in this retrospective cohort study. Based on the pre-procedural fasting blood glucose (FBG) levels, participants were divided into two groups: i) normal FBG (≤110 mg/dl) and ii) high FBG (>110 mg/dl). Long-term (four years) outcomes of ablation (recurrence of AT/AF) were compared between these groups. Results: 412 patients were included in the study, 98 with normal FBG and 314 with high FBG. After four years of follow-up, 84/98 (87%) of the normal FBG group and 232/314 (74%) of the high FBG group remained arrhythmia-free (p-value = 0.008). The presence of high FBG significantly increased the risk of arrhythmia recurrence, with a hazard ratio of 1.82 (95% CI 1.05 to 3.15; p-value = 0.03). On multivariable regression analysis, high FBG was the most important clinical predictor of arrhythmia recurrence (odds ratio 1.78; 95% CI 1.02 to 3.13; p-value = 0.044). Conclusions: In patients with DM, high pre-procedural FBG is associated with a significant reduction in the long-term success rate of catheter ablation in patients with AF and can be used as a predictor of post-ablation arrhythmia recurrence in this cohort.
- Subjects
DIABETES; BLOOD sugar; ATRIAL fibrillation; HEALTH outcome assessment; MEDICAL care
- Publication
Journal of Atrial Fibrillation & Electrophysiology, 2023, Vol 16, Issue 8, p56
- ISSN
2831-7335
- Publication type
Article