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- Title
Salivary type I collagen degradation end-products and related matrix metalloproteinases in periodontitis.
- Authors
Gursoy, Ulvi K.; Könönen, Eija; Huumonen, Sisko; Tervahartiala, Taina; Pussinen, Pirkko J.; Suominen, Anna L.; Sorsa, Timo
- Abstract
Aim Type I collagen degradation end-products and related matrix metalloproteinases ( MMPs) were examined aiming to detect potential markers of periodontitis in saliva, with high sensitivity and specificity. Materials and Methods The salivary concentrations of MMP-8, MMP-9 and MMP-13, tartrate-resistant acid phosphatase serum type 5b, C-terminal cross-linked telopeptide of type I collagen ( CTx), N-terminal cross-linked telopeptide of type I collagen ( NTx) and cross-linked carboxyterminal telopeptide of type I collagen were analysed in 230 subjects. Oral health examination included panoramic radiography. Results The concentrations of MMP-8, MMP-9 and MMP-13 in saliva were higher in subjects with generalized periodontitis than in controls. Of the tested salivary markers, MMP-8 was the only marker capable of differentiating subjects with severe alveolar bone loss from those with slight bone loss ( p < 0.001). The association between the salivary MMP-8 levels and periodontitis remained significant after the adjustment with age, gender and smoking. In addition, significant correlations were found between the tested markers and periodontal parameters. Conclusion Enzymes and end-products of type I collagen degradation have different associations with each other and with periodontal status that may reflect their roles in the cascade leading to alveolar bone loss. MMP-8 is a strong biomarker candidate for detecting alveolar bone destruction.
- Subjects
FINLAND; ENZYMES; ALVEOLAR process; ACADEMIC medical centers; CHI-squared test; COLLAGEN; CONFIDENCE intervals; EPIDEMIOLOGY; PERIODONTITIS; PROTEOLYTIC enzymes; PANORAMIC radiography; RESEARCH funding; SALIVA; STATISTICS; U-statistics; DATA analysis; CASE-control method; DATA analysis software; DESCRIPTIVE statistics; METABOLISM; PHYSIOLOGY
- Publication
Journal of Clinical Periodontology, 2013, Vol 40, Issue 1, p18
- ISSN
0303-6979
- Publication type
Article
- DOI
10.1111/jcpe.12020