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- Title
Levels of CD40L and other inflammatory biomarkers in obese and non-obese women with polycystic ovary syndrome.
- Authors
Sarray, Sameh; Almawi, Wassim Y.
- Abstract
Problem We investigated whether changes in sCD40L, hs- CRP, IL-6, and TNF-α levels are associated with polycystic ovary syndrome ( PCOS). Method of study Case-control study involving 143 women with and 165 women without PCOS. Result(s): Reduced sCD40L, and increased hs- CRP and IL-6, but not TNF-α, levels were seen between cases and controls. ROC analysis demonstrated high sensitivity and specificity for sCD40L and hs- CRP as PCOS predictors. Altered sCD40L levels were associated with PCOS, irrespective of body weight. Significant differences in IL-6 levels were seen between non-obese subjects and for TNF-α in obese subjects. sCD40L correlated negatively with age, insulin, HOMA- IR, LH, free testosterone, FAI, and hirsutism, but positively with SHBG. CRP correlated positively with BMI, insulin, HOMA- IR, free testosterone, and hirsutism. IL-6 correlated positively with hirsutism. TNF-α correlated positively with age, but negatively with insulin and HOMA-IR. Conclusion CD40L, more than IL-6, or TNF-α, constitutes a predictor to explain PCOS and associated features.
- Subjects
CD40 antigen; BIOMARKERS; OVERWEIGHT women; POLYCYSTIC ovary syndrome treatment; CYTOKINES
- Publication
American Journal of Reproductive Immunology, 2016, Vol 76, Issue 4, p285
- ISSN
1046-7408
- Publication type
Article
- DOI
10.1111/aji.12549