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- Title
Increased Proportion of HLA-Class-I-Specific Natural Killer Cell Receptors (CD94) on Peripheral Blood Mononuclear Cells after Allogeneic Bone Marrow Transplantation.
- Authors
Tanaka, Junji; Tutumi, Yutaka; Zhang, Li; Mori, Akio; Kahata, Kaoru; Toyoshima, Nobuyasu; Ohta, Shuichi; Kobayashi, Sumiko; Hashino, Satoshi; Asaka, Masahiro; Imamura, Masahiro
- Abstract
In the present study, we investigated the inhibitory natural killer cell receptor (NKR) expression of CD94/NKG2A on PBMC after allogeneic bone marrow transplantation (BMT). The proportion of CD94 expression on PBMC was higher in patients without chronic graft-versus-host disease (cGVHD) and also in cGVHD patients with good response to conventional immunosuppressive therapy than in cGVHD patients with poor response. Also, the proportions of CD94+/CD3+ cells and CD94+/CD8+ cells were higher in cGVHD patients showing good response. In addition, the proportion of NKG2A-expressing cells was higher in patients without cGVHD than in patients with cGVHD. Therefore, chronic allostimulation after allo-BMT may augment the proportion of CD94/NKG2A-positive cells, and these cells may play some role in the regulation of alloresponse in some patients.Copyright © 2001 S. Karger AG, Basel
- Subjects
BONE marrow transplantation; GRAFT versus host disease; KILLER cells; IMMUNOSUPPRESSIVE agents
- Publication
Acta Haematologica, 2001, Vol 105, Issue 2, p89
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000046540