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- Title
Phenytoin-Induced Agranulocytosis: A Nonimmunologic Idiosyncratic Reaction?
- Authors
Sharafuddin, Melhem J.A.; Spanheimer, Robert G.; McClune, Grant L.
- Abstract
Agranulocytosis is a rare side effect of phenytoin treatment. We describe the case of an elderly man who developed agranulocytosis 2 weeks following initiation of phenytoin treatment, on no cytotoxic drugs or any other medications except decadron. The white blood cell count was 300/mm3 with absent granulocytes. The liver enzymes were also noted to be newly elevated. Complete workup showed no evidence of infection. The patient was managed as a case of neutropenic fever and phenytoin was discontinued. A bone marrow biopsy showed absent granulocyte precursors after myelocytes, and an antigranulocyte antibody titer was negative, which suggests a direct toxic effect rather than an immunologic phenomenon. Both agranulocytosis and hepatitis were readily reversible on phenytoin cessation. Copyright © 1991 S. Karger AG, Basel
- Publication
Acta Haematologica, 1991, Vol 86, Issue 4, p212
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000204838