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- Title
A comparison of the palatability of racemic praziquantel and its two enantioseparated isomers in yellowtail kingfish Seriola lalandi (Valenciennes, 1833).
- Authors
Partridge, Gavin J; Burge, Timothy; Lymbery, Alan J
- Abstract
The bitterness of racemic praziquantel ( Rac- PZQ) constrains its use as an in-feed treatment against monogenean flukes in finfish aquaculture. Evidence exists in mammals that the R-(−) enantiomer of PZQ is less bitter than the S-(+) enantiomer. If fish exhibit this same response, then the recently described techniques for the large-scale resolution of R-(−)- PZQ from Rac- PZQ could facilitate the wide-spread application of this effective anthelmintic compound via feed. The hypothesis that yellowtail kingfish Seriola lalandi would find R-(−)- PZQ more palatable than Rac- PZQ and S-(+)- PZQ was tested in four trials. During the first three trials, the palatability of diets top-coated with 10 g kg−1 of Rac- PZQ or its two enantioseparated isomers were compared in small (85-160 g) and large (1.2 kg) yellowtail kingfish. A fourth trial compared the palatability of R-(−)- PZQ and Rac- PZQ at dietary inclusion levels of 2.5, 5.0 and 10.0 g kg−1 in small yellowtail kingfish (170 g). Ingestion data showed that R-(−)- PZQ to be no more palatable than either Rac- PZQ or S-(+)- PZQ to yellowtail kingfish, regardless of size. Indeed, evidence suggested that the S-(+)- PZQ to be slightly more palatable than both R-(−)- PZQ and Rac- PZQ. From these data, we hypothesize that the strong smell of R-(−)- PZQ (which was not present in S-(+)- PZQ) is an equally important determinant to palatability as taste in yellowtail kingfish. Results demonstrate that dietary inclusion level is a more important determinant to palatability than PZQ chirality; however, administration of R-(−)- PZQ may still be advantageous if it is demonstrated to be the only enantiomer efficacious against monogeneans.
- Subjects
PRAZIQUANTEL; ISOMERS; YELLOWTAIL; BITTERNESS (Taste); ANTHELMINTICS
- Publication
Aquaculture Research, 2017, Vol 48, Issue 4, p1735
- ISSN
1355-557X
- Publication type
Article
- DOI
10.1111/are.13010