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- Title
Phylogenetic Analysis Supports a Link between DUF1220 Domain Number and Primate Brain Expansion.
- Authors
Zimmer, Fabian; Montgomery, Stephen H.
- Abstract
The expansion of DUF1220 domain copy number during human evolution is a dramatic example of rapid and repeated domain duplication. Although patterns of expression, homology, and disease associations suggest a role in cortical development, this hypothesis has not been robustly tested using phylogenetic methods. Here, we estimate DUF1220 domain counts across 12 primate genomes using a nucleotide Hidden Markov Model. We then test a series of hypotheses designed to examine the potential evolutionary significance of DUF1220 copy number expansion. Our results suggest a robust association with brain size, and more specifically neocortex volume. In contradiction to previous hypotheses, we find a strong association with post natal brain development but not with prenatal brain development. Our results provide further evidence of a conserved association between specific loci and brain size across primates, suggesting that human brain evolution may have occurred through a continuation of existing processes.
- Subjects
PRIMATES; BRAIN research; GENE expression; PRIMATE genomes; SIZE of brain
- Publication
Genome Biology & Evolution, 2015, Vol 7, Issue 8, p2083
- ISSN
1759-6653
- Publication type
Article
- DOI
10.1093/gbe/evv122