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- Title
Trastuzumab-functionalized bionic pyrotinib liposomes for targeted therapy of HER2-positive breast cancer.
- Authors
Du, Jiaqun; Liu, Xiaobang; Sun, Junpeng; Wu, Qian; Hu, Yu; Shi, Huan; Zheng, Li; Liu, Ying; Wu, Chao; Gao, Yu
- Abstract
In this study, we prepared a bionic nanosystem of trastuzumab-functionalized SK-BR-3 cell membrane hybrid liposome-coated pyrotinib (Ptb-M-Lip-Her) for the treatment of HER2-positive breast cancer. Transmission electron microscopy, dynamic light scattering, polyacrylamide gel electrophoresis (SDS-PAGE) and western blotting were used to verify the successful preparation of Ptb-M-Lip-Her. In vitro drug release experiments proved that Ptb-M-Lip-Her had a sustained release effect. Cell uptake experiments and in vivo imaging experiments proved that Ptb-M-Lip-Her had good targeting ability to homologous tumor cells (SK-BR-3). The results of cell experiments such as MTT, flow cytometry, immunofluorescence staining and in vivo antitumor experiments showed that Ptb-M-Lip-Her could significantly promote apoptosis and inhibit the proliferation of SK-BR-3 cells. These results clearly indicated that Ptb-M-Lip-Her may be a promising biomimetic nanosystem for targeted therapy of HER2-positive breast cancer.
- Subjects
HER2 positive breast cancer; POLYACRYLAMIDE gel electrophoresis; LIPOSOMES; BIONICS; CELL membranes
- Publication
Breast Cancer Research, 2024, Vol 26, Issue 1, p1
- ISSN
1465-5411
- Publication type
Article
- DOI
10.1186/s13058-024-01853-2